News on April 8, recently, the world's authoritative SCI journal "Human and Experimental Toxicology" published the latest research paper by the research team of Qilu University of Technology (Shandong Academy of Sciences). The damage of cells is relatively small, showing a relatively obvious "harm reduction effect".
This paper is the first empirical research result of the effect of electronic cigarettes on human vascular endothelial cells in China. The first author is Associate Professor Su Le of Qilu University of Technology (Shandong Academy of Sciences). The paper compares the more common RELX electronic cigarettes in China with a certain brand of cigarettes, collects the smoke of electronic cigarettes and cigarettes respectively, and tests the effects of the two types of products on human vascular endothelial cells under the same nicotine concentration.
Vascular endothelial cells are closely related to cardiovascular health and related diseases. Studies have shown that e-cigarettes are less likely to cause inflammation of cardiovascular cells than cigarettes. The effects of different flavors of electronic cigarette smoke on the survival rate of vascular endothelial cells were much lower than those of cigarette smoke. When the nicotine concentration was less than 0.5 μg/ml, the cell viability in each e-cigarette group did not decrease significantly, while the cell viability in the cigarette group decreased by about 30%.
Pro-inflammatory cytokines are key proteins in the body that increase the inflammatory response leading to disease. This study also compared the effects of cigarettes and e-cigarettes on pro-inflammatory factors.
The study found that cells exposed to cigarette smoke collections had significantly increased levels of pro-inflammatory cytokine secretion, which may accelerate inflammation; in contrast, cells exposed to e-cigarette smoke collections for 12 hours had no pro-inflammatory cytokine secretion levels. Significant changes occurred. After 24 hours, the secretion levels of pro-inflammatory factors in cells in each e-cigarette group were still much lower than those in the cigarette group.
